| Classification |
Test name |
| Validation study |
Peer review |
Regulatory acceptance |
Recommendation
to government |
OECD |
|
Collaboration |
| Corrosivity test |
(1)Reconstructed human tissue test made in Japan: Vitrolife-Skin |
| Feb-05 |
Jun-08 |
Jun-08 |
Aug-08 |
OECD TG No.431 |
|
Grants-in-Aid for Scientific Research
JSAAE |
| Phototoxicity test |
(1)3T3－NRU
|
COLIPA
ECVAM |
Nov-04 |
|
|
OECD TG No.432 |
|
Grants-in-Aid for Scientific Research
JSAAE |
| (2)Yeast growth inhibition phototoxicity assay and the red blood cell photohemolysis assay |
| Jan-08 |
May-09 |
Jan-10 |
on suspension |
|
|
Grants-in-Aid for Scientific Research
JSAAE |
| (3)ROS assay |
|
Grants-in-Aid for Scientific Research
JPMA |
| Skin sensitization test |
(1)LLNA-DA |
| Jun-07 |
Feb--08 |
Oct-08 |
Nov-08 |
OECD TG
No.442a |
|
Grants-in-Aid for Scientific Research
JSAAE |
| (2)LLNA-BrdU |
| Aug-08 |
Feb-09 |
Aug-09 |
May-10 |
OECD TG
No.442b |
|
Grants-in-Aid for Scientific Research
JSAAE |
| (3)h-CLAT |
|
Grants-in-Aid for Scientific Research
ECVAM |
| (4)IL-8 Luc assay |
|
METI |
| (5)LLNA |
| will be carried out |
ICCVAM peer review |
|
|
OECD TG
No.429 |
|
ICCVAM
ECVAM |
| (6)rLLNA |
ECVAM,
ICCVAM |
ICCVAM peer review |
under examination |
|
Updated OECD TG
No.429 |
|
ICCVAM |
| Skin irritation test |
(1)Reconstructed human tissue test ( EPISKIN ) |
| ECVAM |
Oct-09 |
Jan-10 |
Mar-10 |
|
|
ECVAM |
| (2)Reconstructed human tissue test made in Japan ( LabCyte ) |
| Jun-09 |
Dec-09 |
|
|
OECD peer review |
|
Grants-in-Aid for Scientific Research
JSAAE |
| (3)Reconstructed human tissue test ( EPISKIN ,EpiDerm ,SkiEthics ) |
| Dec-10 |
ECVAM peer review |
under examination |
|
OECD TG
No.439 |
|
ECVAM |
| Ocular irritation test |
(1)BCOP
ICE |
ECVAM &
ICCVAM |
Mar-09 |
Dec-09 |
Dec-09 |
Guideline No.437,438 |
|
ICCVAM |
(2)Cytosensor microphysiometer
Fluorescein Leakage Test |
| ECVAM |
ECVAM peer review |
in preparation |
|
in draft |
|
ECVAM |
| (3)Cytotoxicity（STE） |
|
Grants-in-Aid for Scientific Research
JSAAE |
| (4)Cytotoxicity in Japan（SIRC） |
|
Grants-in-Aid for Scientific Research |
| (5)Cytotoxicity in Japan（MATREX） |
|
|
| Genotoxicity test Comet assay |
(1)in vitro |
|
Grants-in-Aid for Scientific Research
JEMS
MMS Group
ICCVAM
ECVAM |
| (2)in vivo |
|
Grants-in-Aid for Scientific Research
JEMS
MMS Group
ICCVAM
ECVAM |
| Acute oral toxicity test |
(1)in vitro |
ECVAM,
ICCVAM |
May-10 |
Apr-11 |
Jun-11 |
OECD TG
No.129 |
|
ICCVAM
ECVAM |
| Endcrine disrupter screening |
(1)STTA（agonist assay） |
| Japan |
OECD peer review |
|
|
OECD TG
No.455 |
|
OECD
ECVAM |
| (2)STTA（antaagonist assay） |
|
Grants-in-Aid for Scientific Research
METI
KFDA
ECVAM |
| (3)Lumi-cell assay |
| Feb-10 |
ICVAM peer review |
|
|
in draft |
|
Grants-in-Aid for Scientific Research
NICEATM / ICCVAM
ECVAM |
| (4)Cci assay |
|
ICCVAM
JaCVAM
KoCVAM |
| Cell transformation assay |
(1)Bhras assay |
|
NEDO
METI |
| Pyrogen screening |
(1)in vitro |
| ECVAM |
Feb-10 |
Dec-10 |
on suspension |
|
|
ECVAM
ICCVAM |
