| Classification |
Test name |
| Validation study |
Peer review |
Regulatory acceptance |
Recommendation
to government |
OECD |
|
Collaboration |
01
Corrosivity test |
(1)Reconstructed human tissue test made in Japan: Vitrolife-Skin |
| Feb-09 |
Jun-08 |
Jun-08 |
Aug-08 |
Guideline No.431 |
|
JSAAE |
02
Phototoxicity test |
(1)3T3－NRU
|
| BfR |
Nov-04 |
|
|
Guideline No.432 |
|
|
| (2)Yeast growth inhibition phototoxicity assay and the red blood cell photohemolysis assay |
|
JSAAE |
03
Skin sensitization test |
(1)LLNA-DA |
| Jun-07 |
Feb--08 |
Oct-08 |
Nov-08 |
Draft test
guideline |
|
JSAAE |
| (2)LLNA-BrdU |
| Aug-08 |
Feb-09 |
Aug-09 |
start soon |
Draft test
guideline |
|
JSAAE |
| (3)h-CLAT |
|
|
| (4)LLNA |
| |
ICCVAM peer review |
|
|
Guideline No.429 |
|
|
| (5)rLLNA |
ECVAM,
ICCVAM |
Oct-09 |
|
|
Draft test
guideline |
|
ICCVAM |
04
Skin irritation test |
(1)Reconstructed human tissue test |
| ECVAM |
Oct-09 |
|
start soon |
Draft test
guideline |
|
ECVAM |
| (2)Reconstructed human tissue test made in Japan |
|
JSAAE |
05
Ocular irritation test |
(1)BCOP, ICE |
ECVAM,
ICCVAM |
Mar-09 |
Dec-09 |
start soon |
Guideline No.437,438 |
|
|
| (2)Cytotoxicity（STE） |
|
JSAAE |
| (3)Cytotoxicity in Japan |
|
|
06
Genotoxicity test Comet assay |
(1)in vitro |
|
JEMS |
| (2)in vivo |
|
JEMS |
07
Genotoxicity test |
(1)in vivo |
|
|
08
Skin absorption test |
(1)in vitro |
| |
|
on going |
|
Guideline No.426 |
|
|
09
Acute oral toxicity test |
(1)in vitro |
|
|
10
Endcrine disrupter screening |
(1)STTA（agonist assay） |
| Japan |
OECD peer review |
|
|
Guideline No.455 |
|
OECD
ECVAM |
| (2)STTA（antaagonist assay） |
|
MHLW, METI |
| (3)Lumi-cell assay |
|
MHLW |
11
Cell transformation assay |
(1)Bhras assay |
|
NEDO |
12
Pyrogen screening |
(1)in vitro |
|
|
