Imamura M, Wanibuchi S, Yamamoto Y, Kojima H, Ono A, Kasahara T, Fujita M:Improving predictive capacity of the Amino acid Derivative Reactivity Assay test method for skin sensitization potential with an optimal molar concentration of test chemical solution, J Appl Toxicol.2021;41(2):303-329. doi.org/10.1002/jat.4082.
Nishikawa A, Nagano K, Kojima H, Ogawa K:A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity,Regulatory Toxicology and Pharmacology, 2021;123, 104937. doi.org/10.1016/j.yrtph.2021.104937.
Liao CC, Wu CY, Lin MH, Hsieh FK, Hsu LT, Chang SY, Chen KJ, Huang HT, Hsu HC, Lin CH, Lin PJ, Lai HM, Kojima H, Todo H, Lin SJ, Li JH, Chen W:Validation study of a new reconstructed human epidermis model EPiTRI for in vitro skin irritation test according to OECD guidelines,Toxicology in Vitro, 2021;75,105197. doi.org/10.1016/j.tiv.2021.105197.
Ambe K, Suzuki M, Ashikaga T, Tohkin M:Development of quantitative model of a local lymph node
assay for evaluating skin sensitization potency applying machine learning CatBoost, Regulatory Toxicology and Pharmacology, 2021;125, 105019. doi.org/10.1016/j.yrtph.2021.105019.
Dent MP, Vaillancourt E, Thomas RS, Carmichael PL, Ouedraogo G, Kojima H, Barroso J, Ansell J, Barton-Maclaren TS, Bennekou SH, Boekelheide K, Ezendam J, Field J, Fitzpatrick S, Hatao M, Kreiling R, Lorencini M, Mahony C, Montemayor B, Mazaro-Costa R, Oliveira J, Rogiers V, Smegal D, Taalman R, Tokura Y, Verma R, Willett C, Yang C: Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients, Regulatory Toxicology and Pharmacology. 2021;125, 105026. doi: 10.1016/j.yrtph.2021.105026.
Nishida H, Ohtake T, Ashikaga T, Hirota M, Onoue S, Seto Y, Tokura Y, Kouzuki H: In chemico sequential testing strategy for assessing the photoallegic potential, Toxicology in Vitro, 2021; 77, 105245.doi: 10.1016/j.tiv.2021.105245.
Kojima H, Nakada T, Yagami A, Todo H, Nishimura J, Yagi M, Sugiyama M, Yamamoto K, Ikarashi Y, Sakaguchi H, Yamaguchi M, Hirota M, Ikeda H, Imai N, Hatao M: A Step-by-Step Approach for Assessing Human Skin Irritation Without Animal Testing for Quasi-Drugs and Cosmetic Products, Applied in vitro Toxicology. 2021; 7(3). doi:10.1089/aivt.2021.0016.
Narita K, Okutomi H, Kawakami K, Sui H, Basketter D, Ashikaga T: Behavior of Chemical Respiratory Sensitizers in in Vitro Methods for Skin Sensitization, AATEX, 2021; 26(1), 9-18.
Ashikaga T, Ambe K, Suzuki M, Kurimoto M, Yamada T, Tohkin M. Establishment of a Threshold of Toxicological Concern Concept for Skin Sensitization by in Vitro/in Silico Approaches. 日本香粧品学会誌. 2021;45(4):331-5.
Kojima H: Non-animal Alternative Toxicology and Regulatory Testing: An Update from Japan. Virtual International Conference to Mark the Launch of the
Society for Alternatives to Animal Testing in Sri Lanka (SAAT-SL)(2021.2.7,Sri Lanka, Virtual)
Kojima H: Current projects for systemic toxicological testings in Japan. Global Collaboration Coffee When and How We Can Stop Using Animals in Toxicology, 2021 SOT Virtual Annual Meeting(2021.3.16,USA, Virtual)
Iijima K, Nishida A, Ohno A, Hirose A, Ashikaga T: Comparison of Sensitization Potentials between Silver Nanoparticles and Silver Ions using Monocytic Cell LineTHP-1, 2021 SOT Virtual Annual Meeting(2021.3.22,USA, Virtual)
Kojima H: AI, iPSC and MPS Projects for Systemic Toxicity, Annual meeting on advancing 21stCentury Toxicology,The Center for Alternatives to Animal Testing and
the Animal-Free Safety Assessment Collaboration (2021.5.12,USA, Virtual)
Ashikaga T: Current Views on the 3Rs Adaptation for the Skin Sensitization Testing, 11th Congress of Toxicology in Developing Countries (CTDC11) (2021.6.16,Malaysia, Virtual)
Kojima H: Asian activities for alternatives to animal experiments, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.23, the Netherlands, Virtual)
Ashikaga T: Skin Sensitization Testing Strategy for Japan, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.24, the Netherlands, Virtual)
Kojima H, Akbarsha MA, Gunatilake M, Kim BH: Marching Towards Asian Federation for Alternatives to Animal Testing (AFAAT) through Harmonization of Asian 3R Centres and Associations for Alternatives, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.27&31, the Netherlands, Virtual)
Ashikaga T, Ambe K, Suzuki M, Kurimoto M, Yamada T, Tohkin M: Establishment of a risk assessment method and threshold of toxicological concern (TTC) concept for skin sensitization by non-animal approaches, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.27&31, the Netherlands, Virtual)
Yamaguchi H, Oshikata A, Watatani H, Kojima H, Takezawa T: Proposal of a new applicability domain of Vitrigel-EIT (eye irritancy test) method utilizing the pH level and light absorbance of test chemical preparations, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.27&31, the Netherlands, Virtual)
Kojima H: 21st-Century Toxicology and Regulatory Testing: An Update from Japan, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.9.1, the Netherlands, Virtual)
Kojima H: Alternative methods for developmental and reproductive toxicity testing regarding ICH S5(R3), 9thInternational Congress of Asian Society of Toxicology (ASIATOX-IX)(2021.10.22, Hangzhou, China, Virtual)
Kojima H: Utilization of Endocrine Disrupter Screening for reproductive Toxicity, 6th Asia-Pacific Symposium on Food Safety 2021(2021.11,11, Jeju, Korea, Virtual)