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JaCVAMの研究活動

2021年

誌上発表(原著論文)

  • Imamura M, Wanibuchi S, Yamamoto Y, Kojima H, Ono A, Kasahara T, Fujita M:Improving predictive capacity of the Amino acid Derivative Reactivity Assay test method for skin sensitization potential with an optimal molar concentration of test chemical solution, J Appl Toxicol.2021;41(2):303-329. doi.org/10.1002/jat.4082.
  • Nishikawa A, Nagano K, Kojima H, Ogawa K:A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity,Regulatory Toxicology and Pharmacology, 2021;123, 104937. doi.org/10.1016/j.yrtph.2021.104937.
  • Liao CC, Wu CY, Lin MH, Hsieh FK, Hsu LT, Chang SY, Chen KJ, Huang HT, Hsu HC, Lin CH, Lin PJ, Lai HM, Kojima H, Todo H, Chen W:Validation study of a new reconstructed human epidermis model EPiTRI for in vitro skin irritation test according to OECD guidelines,Toxicology in Vitro, 2021;75,105197. doi.org/10.1016/j.tiv.2021.105197.
  • Ambe K, Suzuki M, Ashikaga T, Tohkin M:Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost, Regulatory Toxicology and Pharmacology, 2021;125, 105019. doi.org/10.1016/j.yrtph.2021.105019.
  • Dent MP, Vaillancourt E, Thomas RS, Carmichael PL, Ouedraogo G, Kojima H, Barroso J, Ansell J, Barton-Maclaren TS, Bennekou SH, Boekelheide K, Ezendam J, Field J, Fitzpatrick S, Hatao M, Kreiling R, Lorencini M, Mahony C, Montemayor B, Mazaro-Costa R, Oliveira J, Rogiers V, Smegal D, Taalman R, Tokura Y, Verma R, Willett C, Yang C: Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients, Regulatory Toxicology and Pharmacology. 2021;125, 105026. doi: 10.1016/j.yrtph.2021.105026.
  • Nishida H, Ohtake T, Ashikaga T, Hirota M, Onoue S, Seto Y, Tokura Y, Kouzuki H: In chemico sequential testing strategy for assessing the photoallegic potential, Toxicology in Vitro, 2021; 77, 105245.doi: 10.1016/j.tiv.2021.105245.
  • Kojima H, Nakada T, Yagami A, Todo H, Nishimura J, Yagi M, Sugiyama M, Yamamoto K, Ikarashi Y, Sakaguchi H, Yamaguchi M, Hirota M, Ikeda H, Imai N, Hatao M: A Step-by-Step Approach for Assessing Human Skin Irritation Without Animal Testing for Quasi-Drugs and Cosmetic Products, Applied in vitro Toxicology. 2021; 7(3). doi:10.1089/aivt.2021.0016.

誌上発表(総説)

  • 尾上誠良, 上月裕一, 豊田明美, 笛木修, 細井一弘, 小島 肇, 足利太可雄, 小野寺博志:光安全性評価の現状と課題. YAKUGAKU ZASSHI, 2021;141(1), 111-124. doi.org/10.1248/yakushi.20-00148
  • 足利太可雄: In vitro/in silico試験による皮膚感作性の毒性学的懸念の閾値(TTC)コンセプトの確立. Cosmetology, 2021;29, 62-66. 

学会発表・セミナー発表

  • Kojima H: Non-animal Alternative Toxicology and Regulatory Testing: An Update from Japan. Virtual International Conference to Mark the Launch of the Society for Alternatives to Animal Testing in Sri Lanka (SAAT-SL)(2021.2.7,Sri Lanka, Virtual)
  • Kojima H: Current projects for systemic toxicological testings in Japan. Global Collaboration Coffee When and How We Can Stop Using Animals in Toxicology, 2021 SOT Virtual Annual Meeting(2021.3.16,USA, Virtual)
  • Iijima K, Nishida A, Ohno A, Hirose A, Ashikaga T: Comparison of Sensitization Potentials between Silver Nanoparticles and Silver Ions using Monocytic Cell LineTHP-1, 2021 SOT Virtual Annual Meeting(2021.3.22,USA, Virtual)
  • Kojima H: AI, iPSC and MPS Projects for Systemic Toxicity, Annual meeting on advancing 21stCentury Toxicology,The Center for Alternatives to Animal Testing and the Animal-Free Safety Assessment Collaboration (2021.5.12,USA, Virtual)
  • Ashikaga T: Current Views on the 3Rs Adaptation for the Skin Sensitization Testing, 11th Congress of Toxilocogy in Developing Countries (CTDC11) (2021.6.16,Malaysia, Virtual)
  • 小島 肇: 医薬部外品添加物承認申請における動物実験代替法の可能性と問題点, 第46回日本香粧品学会(2021.6.26,Virtual)
  • 山本直樹, 平松範子, 佐々木洋, 近藤征史, 小島肇: 医薬品等の生殖毒性試験代替法に有用なヒト由来iPS細胞株の新規開発と応用, 第48回日本毒性学会学術年会(2021.7.7,神戸)
  • 小島 肇: 医薬品の安全性評価に用いる動物実験代替法の現状と課題, 第48回日本毒性学会学術年会(2021.7.8,神戸)
  • 田中利男, 小島 肇, 藤原道夫, 森華奈子, 山本恭子, 山田佳代子, 水谷有香, 森 葵泉, 加藤由起子: ゼブラフィッシュ発生毒性試験における品質管理プロトコルの確立, 第48回日本毒性学会学術年会(2021.7.9,神戸)
  • 西田明日香, 足利太可雄, 大野彰子, 飯島一智: 銀ナノ粒子の抗原提示細胞活性化能の解析, 第48回日本毒性学会学術年会(2021.7.9,神戸)
  • 田邉郁也, 石川晋吉, 石森かな江, 橋爪恒夫, 善本隆之, 足利太可雄: 呼吸器特異的な免疫応答を再現したin vitro呼吸器感作性試験の開発, 第48回日本毒性学会学術年会(2021.7.7-9,神戸)
  • Kojima H: Asian activities for alternatives to animal experiments, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.23, the Netherlands, Virtual)
  • Ashikaga T: Skin Sensitization Testing Strategy for Japan, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.24, the Netherlands, Virtual)
  • Kojima H, Akbarsha MA, Gunatilake M, Kim BH: Marching Towards Asian Federation for Alternatives to Animal Testing (AFAAT) through Harmonization of Asian 3R Centres and Associations for Alternatives, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.27&31, the Netherlands, Virtual)
  • Ashikaga T, Ambe K, Suzuki M, Kurimoto M, Yamada T, Tohkin M: Establishment of a risk assessment method and threshold of toxicological concern (TTC) concept for skin sensitization by non-animal approaches, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.27&31, the Netherlands, Virtual)
  • Yamaguchi H, Oshikata A, Watatani H, Kojima H, Takezawa T: Proposal of a new applicability domain of Vitrigel-EIT (eye irritancy test) method utilizing the pH level and light absorbance of test chemical preparations, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.8.27&31, the Netherlands, Virtual)
  • Kojima H: 21st-Century Toxicology and Regulatory Testing: An Update from Japan, 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11)(2021.9.1, the Netherlands, Virtual)
  • 山口宏之, 押方歩, 小島肇, 竹澤俊明: 固体被検物質を適用するために改訂したVitrigel-EIT法, 日本組織培養学会第93回大会(2021.9.3,広島)
  • 小島 肇: 化粧品の安全性と評価, 東京理科大学オープンカレッジ(2021.9.5,Virtual)
  • 相場節也, 木村裕, 足利太可雄, 小島肇: Multi-ImmunoToxicity Assayとガイダンス化状況 , 第28回日本免疫毒性学会学術年会(2021.9.7,Virtual)
  • 足利太可雄: 皮膚感作性-IATAに基づくOECDガイドライン-, 第28回日本免疫毒性学会学術年会(2021.9.7,Virtual)
  • 足利太可雄, 西田明日香, 大野彰子, 飯島一智: 二酸化ケイ素ナノマテリアル曝露によるTHP-1細胞の活性化に関する研究, 第28回日本免疫毒性学会学術年会(2021.9.6-7,Virtual)
  • 小島 肇: 動物実験代替法の国内外の最新動向, 第15回皮膚基礎研究クラスターフォーラム(2021.9.15,Virtual)
  • Kojima H: Current projects developing new approach methods(NAMs) for systematic toxicology in Japan, 2021 International Symposium on Alternatives to Animal Testing in Taiwan(2021.10.5,Virtual)
  • 小島 肇: ガイドライン化にむけた動き, 第三回scChemRISC研究会(2021.10.12,Virtual)

発表資料